Lionel Messi will undergo scans for a left knee injury.
Messi has already been ruled out of Paris Saint-Germain's Ligue 1 match against Metz and is also in doubt for next Tuesday's Champions League tie against Manchester City.
When asked about Messi's situation at a news conference, PSG manager Mauricio Pochettino replied: "The club has already communicated Leo's situation and it's clear.
"We had seen that Messi was touching his knee. I'm very happy with what he did during the match [against Lyon]. After 75 minutes, taking into account the information we had, we made the decision [to bring him off].
"Messi is a great champion, and like all great champions, he didn't want to come off. I'm happy with his commitment and his performance. He hasn't scored yet, but he played very well."