Clint Dempsey will sit out the rest of the 2016 season because of an irregular heartbeat.

Dempsey, 33, was initially sidelined by the symptoms last month but returned to light training on Sept. 14.

Dempsey stopped training last week, leading to Tuesday's announcement.

"We simply haven't got to a point where we were comfortable that there was a realistic chance" of Dempsey returning this year, Lagerwey told reporters. "As we said in the first round of comments, we are not comfortable putting any kind of pressure on this.

"His return to play is not important relative to his health, both short- and long-term. We feel by ruling him out today it puts us in the best position to get him back, hopefully for the start of the 2017 season."

Francis Coquelin will likely miss three weeks with a knee injury.

Coquelin was forced out of Arsenal's 3-0 win over Chelsea after 32 minutes following a challenge with N'Golo Kante.

There were concerns the injury could force Coquelin out for a longer period of time.

Kevin De Bruyne will miss four weeks with a hamstring injury he suffered in Saturday's win over Swansea City.

De Bruyne was substituted with a suspected muscle injury in the 81st minute.

De Bruyne would miss the Champions League game against Celtic on Wednesday as well as Premier League games against Tottenham and Everton, while he would be a major doubt for the trip to Barcelona on Oct. 19.

Speaking after Saturday's game, Pep Guardiola had said: "I think he's injured.

"Tonight we are going to come back to Manchester, tomorrow the doctor is going to see. It's a pity. It's important for us. For how he reacted it looks muscular but I'm not a doctor."

Casemiro will miss one to two months with a fractured fibula.

Casemiro suffered the injury in Real Madrid's match against Espanyol last Sunday.

Casemiro came off in the 18th minute after challenging Diop for the ball and receiving an accidental kick as he went to block.

Lionel Messi suffered a groin injury and will be out at least three weeks.

“To lose Messi means that football loses. With Messi we are stronger, but we will continue being strong,” said Luis Enrique.

Barcelona tied Atletico Madrid 1-1 in a critical early season La Liga match.

Messi also missed several weeks early in the 15-16 season but Barcelona still went on to win La Liga.

Harry Kane could be out for up to two months after sustaining ligament damage on his ankle.

Kane fell awkwardly and twisted the joint late on and departed the stadium on crutches and wearing a protective boot on his right foot. 

The first scan showed Kane did not break a bone in the fall.

Kane could miss two Champions League group matches and seven Premier League fixtures. Spurs play Arsenal on Nov. 6th, which is near the end of a normal recovery period for the injury.

Cristiano Ronaldo says he's 100 percent recovered from the knee injury he suffered in the Euro 2016 final in early July.

Ronaldo expects to play on Saturday in La Liga against Osasuna. Ronaldo has intensified his training over the past week.

“I’m going to play,” said Ronaldo.

Lionel Messi's groin injury has persisted and there is no timetable for his return.

Messi will sit out Argentina's match against Venezuela on Tuesday.

"Tests conducted today on first team player Leo Messi have confirmed that the discomfort in his left adductor muscle persists," said Barcelona in a statement.

"It's advised he lowers the burden of training in the coming days and the evolution of the injury will mark his availability to return to action."

Messi himself posted a message of reassurance to his fans via his Facebook account on Monday, saying: "Everything is fine, I have to slow things down as I recover with physio, but it's nothing to worry about. Thanks to you all for your support."