Henrikh Mkhitaryan will be sidelined for six weeks with a fractured metatarsal in his right foot. 

The midfielder sustained the injury against Tottenham in the Carabao Cup.

Arsenal are already without Rob Holding, Danny Welbeck, Hector Bellerin, and Shkodran Mustafi due to injury. 

Hector Bellerin was taken off at halftime during Arsenal's 3-2 loss to Southampton with a calf injury.

Manager Unai Emery said Bellerin would take "some weeks off" to recover.

The 23-year-old defender started all 17 league matches for Arsenal this season. 

Eric Dier was ruled out until January after undergoing appendix surgery after Tottenham's Champions League match against Barcelona.

Dier was replaced in the lineup against Burnley by 18-year-old Oliver Skipp, who represents the 13th player to graduate from Tottenham's academy into the senior side under Mauricio Pochettino.

Of Skipp's perfomance, Pochettino said "I think he played like a 30-year-old man. So relaxed, trying to play forward and trying to give the team what the team needs … plenty of energy, full energy, I am so proud of him".

Mauricio Pochettino has blamed Kieran Trippier's recurring groin injury on England's third-place match against Croatia in the UEFA Nations League. 

Trippier left that match with the injury, and was subbed off most recently against Southampton in the 87th minute.

Pochettino added that without full treatment, Tripper needs "to accept that situation and live sometimes with some pain and play”.

Joe Gomez is out six weeks after fracturing his lower leg during Liverpool's 3-1 win over Burnley. 

The 21-year-old Gomez has started 12 out of 13 matches this season and formed an important partnership with Virgl van Dijk at center back. 

Jurgen Klopp asked the refs for more protection during the Burnley match, adding that "we all want to win football games, and there are different ways of doing it. Somebody has to tell you to stop doing it, make two more steps and make a normal challenge....I think the referee has to make sure that things like this don't happen constantly. It's not how it should be. Let's play football."

Burnley manager Sean Dyche defended his team's tackling style after the match while accusing Daniel Sturridge of diving. 

Mesut Ozil did not play in Arsenal's 4-2 win over Tottenham with a back injury. 

Manager Unai Emery said that he didn't know when Ozil was injured or whether he was at the stadium for the match.

Emery dropped the 30-year-old midfielder against Bournemouth in the previous week over concerns of his ability to handle the physicality and intensity of the match.