Borussia Dortmund sacked Lucien Favre following a 5-1 home loss to Stuttgart.
"We are all grateful to Lucien Favre for his excellent work over the past two-and-a-half year, in which he and his team won two runner-up championships. As a professional and as a person, Lucien Favre is beyond any doubt," said Dortmund chairman Hans-Joachim Watzke.
The side have just one point from their last three matches, have lost their last three home matches, and are currently five points behind Bayern Munich on the league table.
Favre was hired as manager in the summer of 2018.
Edin Terzic, Otto Addo and Sebastian Geppert will take over as manager.