Harry Kane has been ruled out of Saturday's match at Manchester United and is also doubtful for next week's match in the Champions League against Real Madrid.

Kane injured his hamstring last week against Liverpool.

"We can't take the risk," Mauricio Pochettino said. "The doctor and medical staff made the decision to not take the risk. There is no sense in taking that risk and making the problem bigger."

Pochettino acknowledged his disappointment at being without the prolific forward but insisted it was "only a small issue."

"The players are not machines and it is so difficult to cope with international duty and playing every three days," he added. "It is not a big problem, only a small issue, but he is not going to play [on Saturday].

"We'll see after for Wednesday against Real Madrid."