Lille Front Office
Tuchel dropped Kylian Mbappe from the lineup.
Pepe has contributed to over 62% of Lille's goals this season.
Lille last won the title in 2011 and they are currently 14th and 30 points behind leaders Monaco.
Sofiane Boufal scored 12 goals in all competitions in his first full season with Lille as they finished fifth in Ligue 1 and reached the final of the Coupe de la Ligue.
Spurs offered £12 million for Sofiane Boufal at the end of the window.