Marcus Rashford is expected to miss several weeks with a back injury.
"I wouldn't expect him to be back in the next few weeks. We have a midseason break and I'm not sure you are going to see him before then, no," said Ole Gunnar Solskjaer.
Rashford suffered the injury against Wolverhampton.
Rashford, United's leading goalscoring on the season, has scored 14 goals in the league.