Kevin de Bruyne suffered a hamstring injury against Tottenham in Saturday's win that will keep him out of the Manchester derby on Wednesday.
Pep Guardiola praised Phil Foden's performance against Tottenham, with the 18-year-old set to replace de Bruyne in the lineup.
“He [Foden] is an incredibly talented player with an ability to arrive in the box, which is how he got his goal. Every time he plays he either scores goals or makes chances. Against Tottenham he showed his ability to play in tight spaces, because it is not easy to play against Dier or Wanyama or Eriksen. It was a fantastic experience for him and I trust him a lot," said Guardiola.