Joe Gomez is out six weeks after fracturing his lower leg during Liverpool's 3-1 win over Burnley.
The 21-year-old Gomez has started 12 out of 13 matches this season and formed an important partnership with Virgl van Dijk at center back.
Jurgen Klopp asked the refs for more protection during the Burnley match, adding that "we all want to win football games, and there are different ways of doing it. Somebody has to tell you to stop doing it, make two more steps and make a normal challenge....I think the referee has to make sure that things like this don't happen constantly. It's not how it should be. Let's play football."
Burnley manager Sean Dyche defended his team's tackling style after the match while accusing Daniel Sturridge of diving.