Lyon beat PSG 2-1 to hand Thomas Tuchel's side their first loss in the league this season.
Nabil Fekir and Moussa Dembele each scored for Lyon.
Thomas Tuchel said he was confident in his team despite losing Neymar for 10 weeks.
"I do not know it we missed them but it's clear that we do not have a second Neymar or a second [Marco] Verratti, but I have full confidence in the other players," said Tuchel.