Harry Kane will be out until early March with ligament damage in his left ankle.
Kane was on the receiving end of a Phil Jones tackle towards the end of their 1-0 loss to Manchester United.
Kane is set to miss both legs of Tottenham's Champions League match-up against Borussia Dortmund.
With Kane's injury and Heung-Min Son leaving for the Asian Cup, Fernando Llorente and Lucas Moura are Mauricio Pochettino's top options at striker.