Manchester United at Arsenal (Saturday, 12:30 PM EST): Maybe the start of the season hasn't actually been that awful for Arsene Wenger and Arsenal? Not picking up three points at the Emirates against a flawed United club that's coming out of the international break with a ton of injuries would be a disaster. Arsenal has famously struggled against the better Premier League clubs, but United is one of those in name only despite quite a few big names in their attack. Arsenal and United are similarly vulnerable in defense with both clubs inexplicably not investing in that area of the pitch over the summer despite their immense resources. Arsenal and United played to a 0-0 draw in their most recent match last February, but we should see plenty of goals this time around in what could be the Danny Welbeck Revenge match.

Inter at AC Milan (Sunday, 2:45 PM EST): The first Derby della Madonnina of the season features clubs in 7th and 9th place in Serie A and the quality of play won't be there, but this is Roberto Mancini's first match back as manager. Mancini is expected to move Inter from Walter Mazzarri's 3-5-2 to a 4-3-1-2 formation and will do so in this first match without Gary Medel who is on suspension. 

Sevilla at Barcelona (Saturday, 2:00 PM EST): Are we really beginning to witness the final days of Lionel Messi at Barcelona? That remains incredibly unlikely, but Barça hosts a strong Sevilla side that features Gerard Deulofeu and Denis Suarez, who are each out on loan from them. Suarez went to Sevilla on a two-year loan as part of Barça's acquisition of Ivan Rakitic, who is playing against his former club for the first time. Barcelona finally has their full squad available after suspensions and injuries, so it will be intriguing to see Luis Enrique's XI.